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The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells
Isocitrate dehydrogenase 2 (IDH2) is located in the mitochondrial matrix. IDH2 acts in the forward Krebs cycle as an NADP(+)-consuming enzyme, providing NADPH for maintenance of the reduced glutathione and peroxiredoxin systems and for self-maintenance by reactivation of cystine-inactivated IDH2 by...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Hindawi Publishing Corporation
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3363418/ https://ncbi.nlm.nih.gov/pubmed/22675360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/273947 |
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