Mitochondrial NADP(+)-Dependent Isocitrate Dehydrogenase Deficiency Exacerbates Mitochondrial and Cell Damage after Kidney Ischemia-Reperfusion Injury

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance. Ischemia-reperfusion (I/R) is one of most common causes of AKI. I/R disrupts the mitochond...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Han, Sang Jun, Jang, Hee-Seong, Noh, Mi Ra, Kim, Jinu, Kong, Min Jung, Kim, Jee In, Park, Jeen-Woo, Park, Kwon Moo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373447/
https://ncbi.nlm.nih.gov/pubmed/27821630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016030349
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