Mitochondrial NADP(+)-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2) plays an important role in the formation of NADPH, which is critical for the maintenance of mitochondrial redox balance. Cis-diamminedichloroplatinum II (cisplatin), an effective anticancer drug, induces oxidative stress-related nephrot...

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Vydáno v:Cell Death Dis
Hlavní autoři: Kong, Min Jung, Han, Sang Jun, Kim, Jee In, Park, Jeen-Woo, Park, Kwon Moo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916920/
https://ncbi.nlm.nih.gov/pubmed/29695796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0537-6
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