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Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability
A major advance in understanding the progression and prognostic outcome of certain cancers, such as low-grade gliomas, acute myeloid leukaemia, and chondrosarcomas, has been the identification of early-occurring mutations in the NADP(+)-dependent isocitrate dehydrogenase genes IDH1 and IDH2. These m...
Guardado en:
| Publicado en: | Hum Mol Genet |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5179947/ https://ncbi.nlm.nih.gov/pubmed/27427385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw195 |
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