SIRT1 deacetylates RORγt and enhances Th17 cell generation

The balance of effector and regulatory T cell function, dependent on multiple signals and epigenetic regulators, is critical to immune self-tolerance. Dysregulation of T helper 17 (Th17) effector cells is associated with multiple autoimmune diseases, including multiple sclerosis. Here, we report tha...

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Vydáno v:J Exp Med
Hlavní autoři: Lim, Hyung W., Kang, Seung Goo, Ryu, Jae Kyu, Schilling, Birgit, Fei, Mingjian, Lee, Intelly S., Kehasse, Amanuel, Shirakawa, Kotaro, Yokoyama, Masaru, Schnölzer, Martina, Kasler, Herbert G., Kwon, Hye-Sook, Gibson, Bradford W., Sato, Hironori, Akassoglou, Katerina, Xiao, Changchun, Littman, Dan R., Ott, Melanie, Verdin, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419343/
https://ncbi.nlm.nih.gov/pubmed/25918343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132378
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