SIRT1 Regulates HIV Transcription via Tat Deacetylation

The human immunodeficiency virus (HIV) Tat protein is acetylated by the transcriptional coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase...

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Main Authors: Pagans, Sara, Pedal, Angelika, North, Brian J, Kaehlcke, Katrin, Marshall, Brett L, Dorr, Alexander, Hetzer-Egger, Claudia, Henklein, Peter, Frye, Roy, McBurney, Michael W, Hruby, Henning, Jung, Manfred, Verdin, Eric, Ott, Melanie
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2005
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC546329/
https://ncbi.nlm.nih.gov/pubmed/15719057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0030041
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