Set7/9 (KMT7) binds HIV-1 TAR RNA, monomethylates Tat and enhances Tat-dependent HIV transcription

Posttranslational modifications of the HIV-1 Tat protein have emerged as critical regulatory mechanisms that fine-tune interactions of the viral transactivator with TAR RNA and cellular cofactors. Here, we identify the lysine methyltransferase Set7/9 (renamed KMT7) as a novel co-activator of HIV tra...

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Detalhes bibliográficos
Main Authors: Pagans, Sara, Kauder, Steven E., Kaehlcke, Katrin, Sakane, Naoki, Schroeder, Sebastian, Dormeyer, Wilma, Trievel, Raymond C., Verdin, Eric, Schnolzer, Martina, Ott, Melanie
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844784/
https://ncbi.nlm.nih.gov/pubmed/20227666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.02.005
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