Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T-Cell Hyperactivation

Symptoms of T-cell hyperactivation shape the course and outcome of HIV-1 infection, but the mechanism(s) underlying this chronic immune activation are not well understood. We find that the viral transactivator Tat promotes hyperactivation of T cells by blocking the nicotinamide adenine dinucleotide...

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Main Authors: Kwon, Hye-Sook, Brent, Michael M., Getachew, Ruth, Jayakumar, Prerana, Chen, Lin-Feng, Schnolzer, Martina, McBurney, Michael W., Marmorstein, Ronen, Greene, Warner C., Ott, Melanie
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680745/
https://ncbi.nlm.nih.gov/pubmed/18329615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.02.002
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