The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

Although many self-reactive T cells are eliminated by negative selection in the thymus, some of these cells escape into the periphery, where they must be controlled by additional mechanisms. However, the molecular mechanisms underlying peripheral T cell tolerance and its maintenance remain largely u...

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Detalhes bibliográficos
Main Authors: Zhang, Jinping, Lee, Sang-Myeong, Shannon, Stephen, Gao, Beixue, Chen, Weimin, Chen, An, Divekar, Rohit, McBurney, Michael W., Braley-Mullen, Helen, Zaghouani, Habib, Fang, Deyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752073/
https://ncbi.nlm.nih.gov/pubmed/19729833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38902
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