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Neuroprotective functions for the histone deacetylase SIRT6
The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age, with a concomitant accumulation of DNA damage. Furthermore, SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely. Here, we report that brain-specific SIRT6-deficient mice survive, but pre...
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| Pubblicato in: | Cell Rep |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389893/ https://ncbi.nlm.nih.gov/pubmed/28355558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.008 |
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