Neuroprotective functions for the histone deacetylase SIRT6

The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age, with a concomitant accumulation of DNA damage. Furthermore, SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely. Here, we report that brain-specific SIRT6-deficient mice survive, but pre...

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Publicado en:Cell Rep
Main Authors: Kaluski, Shai, Portillo, Miguel, Besnard, Antoine, Stein, Daniel, Einav, Monica, Zhong, Lei, Ueberham, Uwe, Arendt, Thomas, Mostoslavsky, Raul, Sahay, Amar, Toiber, Debra
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389893/
https://ncbi.nlm.nih.gov/pubmed/28355558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.008
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