Neuroprotective functions for the histone deacetylase SIRT6

The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age, with a concomitant accumulation of DNA damage. Furthermore, SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely. Here, we report that brain-specific SIRT6-deficient mice survive, but pre...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kaluski, Shai, Portillo, Miguel, Besnard, Antoine, Stein, Daniel, Einav, Monica, Zhong, Lei, Ueberham, Uwe, Arendt, Thomas, Mostoslavsky, Raul, Sahay, Amar, Toiber, Debra
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389893/
https://ncbi.nlm.nih.gov/pubmed/28355558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados