SIRT6 is a DNA double-strand break sensor

DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independently of signaling and known sensors. It activates do...

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Vydáno v:eLife
Hlavní autoři: Onn, Lior, Portillo, Miguel, Ilic, Stefan, Cleitman, Gal, Stein, Daniel, Kaluski, Shai, Shirat, Ido, Slobodnik, Zeev, Einav, Monica, Erdel, Fabian, Akabayov, Barak, Toiber, Debra
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051178/
https://ncbi.nlm.nih.gov/pubmed/31995034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51636
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