SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

The Sir2 chromatin regulatory factor links maintenance of genomic stability to life span extension in yeast. The mammalian Sir2 family member SIRT6 has been proposed to have analogous functions, because SIRT6-deficiency leads to shortened life span and an aging-like degenerative phenotype in mice, a...

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Bibliografiska uppgifter
Huvudupphovsmän: McCord, Ronald A., Michishita, Eriko, Hong, Tao, Berber, Elisabeth, Boxer, Lisa D., Kusumoto, Rika, Guan, Shenheng, Shi, Xiaobing, Gozani, Or, Burlingame, Alma L., Bohr, Vilhelm A., Chua, Katrin F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815768/
https://ncbi.nlm.nih.gov/pubmed/20157594
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