JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

The accumulation of damage caused by oxidative stress has been linked to aging and to the etiology of numerous age-related diseases. The longevity gene, sirtuin 6 (SIRT6), promotes genome stability by facilitating DNA repair, especially under oxidative stress conditions. Here we uncover the mechanis...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Van Meter, Michael, Simon, Matthew, Tombline, Gregory, May, Alfred, Morello, Timothy D., Hubbard, Basil P., Bredbenner, Katie, Park, Rosa, Sinclair, David A., Bohr, Vilhelm A., Gorbunova, Vera, Seluanov, Andrei
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089070/
https://ncbi.nlm.nih.gov/pubmed/27568560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.006
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