JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

The accumulation of damage caused by oxidative stress has been linked to aging and to the etiology of numerous age-related diseases. The longevity gene, sirtuin 6 (SIRT6), promotes genome stability by facilitating DNA repair, especially under oxidative stress conditions. Here we uncover the mechanis...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Van Meter, Michael, Simon, Matthew, Tombline, Gregory, May, Alfred, Morello, Timothy D., Hubbard, Basil P., Bredbenner, Katie, Park, Rosa, Sinclair, David A., Bohr, Vilhelm A., Gorbunova, Vera, Seluanov, Andrei
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089070/
https://ncbi.nlm.nih.gov/pubmed/27568560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.006
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