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SIRT6 promotes DNA repair under stress by activating PARP1
SIRT6 is a mammalian homolog of the yeast Sir2 deacetylase that promotes longevity in yeast and invertebrates. Mice deficient for SIRT6 exhibit premature aging and genome instability. Here we show that in mammalian cells subjected to oxidative stress SIRT6 is recruited to the sites of DNA double-str...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5472447/ https://ncbi.nlm.nih.gov/pubmed/21680843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1202723 |
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