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Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
Genomic instability is a hallmark of aging tissues. Genomic instability may arise from the inefficient or aberrant function of DNA double-stranded break (DSB) repair. DSBs are repaired by homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). HR is a precise pathway, whereas NHEJ fr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406824/ https://ncbi.nlm.nih.gov/pubmed/22753495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200583109 |
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