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Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

Genomic instability is a hallmark of aging tissues. Genomic instability may arise from the inefficient or aberrant function of DNA double-stranded break (DSB) repair. DSBs are repaired by homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). HR is a precise pathway, whereas NHEJ fr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mao, Zhiyong, Tian, Xiao, Van Meter, Michael, Ke, Zhonghe, Gorbunova, Vera, Seluanov, Andrei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406824/
https://ncbi.nlm.nih.gov/pubmed/22753495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200583109
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