SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

In principle, a decline in base excision repair (BER) efficiency with age should lead to genomic instability and ultimately contribute to the onset of the aging phenotype. Although multiple studies have indicated a negative link between aging and BER, the change of BER efficiency with age in humans...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Cycle
Auteurs principaux: Xu, Zhu, Zhang, Lei, Zhang, Wenjun, Meng, Du, Zhang, Hongxia, Jiang, Ying, Xu, Xiaojun, Van Meter, Michael, Seluanov, Andrei, Gorbunova, Vera, Mao, Zhiyong
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2015
Sujets:
Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614943/
https://ncbi.nlm.nih.gov/pubmed/25607651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.980641
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