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Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6
Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, SIRT6 levels/activity decline, which is accentuated in Alzheimer’s patients. To understand SIRT6 role...
Gardado en:
| Publicado en: | Aging (Albany NY) |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Impact Journals
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7993737/ https://ncbi.nlm.nih.gov/pubmed/33690173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202755 |
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