SIRT6 recruits SNF2H to sites of DNA breaks, preventing genomic instability through chromatin remodeling

DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration and senescence. Little is known about the role of chromatin accessibility in DNA repair. Here, we find that the histone deacetylase SIRT6 is one of the earliest factors recruited to sites of Double-Strand Breaks (DSBs...

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Autori principali: Toiber, Debra, Erdel, Fabian, Bouazoune, Karim, Silberman, Dafne M., Zhong, Lei, Mulligan, Peter, Sebastian, Carlos, Cosentino, Claudia, Martinez-Pastor, Barbara, Giacosa, Sofia, D’Urso, Agustina, Näär, Anders M., Kingston, Robert, Rippe, Karsten, Mostoslavsky, Raul
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761390/
https://ncbi.nlm.nih.gov/pubmed/23911928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.06.018
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