SIRT6 recruits SNF2H to sites of DNA breaks, preventing genomic instability through chromatin remodeling

DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration and senescence. Little is known about the role of chromatin accessibility in DNA repair. Here, we find that the histone deacetylase SIRT6 is one of the earliest factors recruited to sites of Double-Strand Breaks (DSBs...

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書誌詳細
主要な著者: Toiber, Debra, Erdel, Fabian, Bouazoune, Karim, Silberman, Dafne M., Zhong, Lei, Mulligan, Peter, Sebastian, Carlos, Cosentino, Claudia, Martinez-Pastor, Barbara, Giacosa, Sofia, D’Urso, Agustina, Näär, Anders M., Kingston, Robert, Rippe, Karsten, Mostoslavsky, Raul
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761390/
https://ncbi.nlm.nih.gov/pubmed/23911928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.06.018
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