SIRT6 recruits SNF2H to sites of DNA breaks, preventing genomic instability through chromatin remodeling

DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration and senescence. Little is known about the role of chromatin accessibility in DNA repair. Here, we find that the histone deacetylase SIRT6 is one of the earliest factors recruited to sites of Double-Strand Breaks (DSBs...

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Detalhes bibliográficos
Main Authors: Toiber, Debra, Erdel, Fabian, Bouazoune, Karim, Silberman, Dafne M., Zhong, Lei, Mulligan, Peter, Sebastian, Carlos, Cosentino, Claudia, Martinez-Pastor, Barbara, Giacosa, Sofia, D’Urso, Agustina, Näär, Anders M., Kingston, Robert, Rippe, Karsten, Mostoslavsky, Raul
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761390/
https://ncbi.nlm.nih.gov/pubmed/23911928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.06.018
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