The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation

The NAD-dependent histone deacetylase Sirt1 is a negative regulator of T cell activation. Here we report that Sirt1 inhibits T cell activation by suppressing the transcription of Bcl2-associated factor 1 (Bclaf1), a protein required for T cell activation. Sirt1-null T cells have increased acetylatio...

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Detalhes bibliográficos
Main Authors: Kong, Sinyi, Kim, Seung-Jae, Sandal, Barry, Lee, Sang-Myeong, Gao, Beixue, Zhang, Donna D., Fang, Deyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089540/
https://ncbi.nlm.nih.gov/pubmed/21454709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218206
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