Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications

The class II deacetylase histone deacetylase 4 (HDAC4) negatively regulates the transcription factor MEF2. HDAC4 is believed to repress MEF2 transcriptional activity by binding to MEF2 and catalyzing local histone deacetylation. Here we report that HDAC4 also controls MEF2 by a novel SUMO E3 ligase...

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Autores principales: Zhao, Xuan, Sternsdorf, Thomas, Bolger, Timothy A., Evans, Ronald M., Yao, Tso-Pang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265742/
https://ncbi.nlm.nih.gov/pubmed/16166628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8456-8464.2005
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