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Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is Due to Inhibition of MEF2 by NF-κB and Histone Deacetylases

Activation of the endothelium by inflammatory cytokines is a key event in the pathogenesis of vascular disease states. Proinflammatory cytokines repress the expression of KLF2, a recently identified transcriptional inhibitor of the cytokine-mediated activation of endothelial cells. In this study the...

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Main Authors: Kumar, Ajay, Lin, Zhiyong, SenBanerjee, Sucharita, Jain, Mukesh K.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168833/
https://ncbi.nlm.nih.gov/pubmed/15988006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.14.5893-5903.2005
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