The histone deacetylase SIRT2 stabilizes Myc oncoproteins

Myc oncoproteins are commonly upregulated in human cancers of different organ origins, stabilized by Aurora A, degraded through ubiquitin–proteasome pathway-mediated proteolysis, and exert oncogenic effects by modulating gene and protein expression. Histone deacetylases are emerging as targets for c...

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Detalhes bibliográficos
Main Authors: Liu, P Y, Xu, N, Malyukova, A, Scarlett, C J, Sun, Y T, Zhang, X D, Ling, D, Su, S-P, Nelson, C, Chang, D K, Koach, J, Tee, A E, Haber, M, Norris, M D, Toon, C, Rooman, I, Xue, C, Cheung, B B, Kumar, S, Marshall, G M, Biankin, A V, Liu, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569991/
https://ncbi.nlm.nih.gov/pubmed/23175188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.147
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