The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

Silent information regulator 1 (SIRT1) represents an NAD(+)-dependent deacetylase that inhibits proapoptotic factors including p53. Here we determined whether SIRT1 is downstream of the prototypic c-MYC oncogene, which is activated in the majority of tumors. Elevated expression of c-MYC in human col...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Menssen, Antje, Hydbring, Per, Kapelle, Karsten, Vervoorts, Jörg, Diebold, Joachim, Lüscher, Bernhard, Larsson, Lars-Gunnar, Hermeking, Heiko
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268300/
https://ncbi.nlm.nih.gov/pubmed/22190494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105304109
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