Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1

Myc oncoproteins and histone deacetylases (HDACs) exert oncogenic effects by modulating gene transcription. Paradoxically, N-Myc induces p53 gene expression. Tumor protein 53-induced nuclear protein 1 (TP53INP1) phosphorylates p53 protein at serine 46, leading to enhanced p53 activity, transcription...

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Hauptverfasser: Shahbazi, Jeyran, Scarlett, Christopher J., Norris, Murray D., Liu, Bing, Haber, Michelle, Tee, Andrew E., Carrier, Alice, Biankin, Andrew V., London, Wendy B., Marshall, Glenn M., Lock, Richard B., Liu, Tao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147321/
https://ncbi.nlm.nih.gov/pubmed/24952595
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