SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK protein. Here we describe a novel positive feedba...

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Main Authors: Marshall, Glenn M., Liu, Pei Y., Gherardi, Samuele, Scarlett, Christopher J., Bedalov, Antonio, Xu, Ning, Iraci, Nuncio, Valli, Emanuele, Ling, Dora, Thomas, Wayne, van Bekkum, Margo, Sekyere, Eric, Jankowski, Kacper, Trahair, Toby, MacKenzie, Karen L., Haber, Michelle, Norris, Murray D., Biankin, Andrew V., Perini, Giovanni, Liu, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116909/
https://ncbi.nlm.nih.gov/pubmed/21698133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002135
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