SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK protein. Here we describe a novel positive feedba...

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Autori principali: Marshall, Glenn M., Liu, Pei Y., Gherardi, Samuele, Scarlett, Christopher J., Bedalov, Antonio, Xu, Ning, Iraci, Nuncio, Valli, Emanuele, Ling, Dora, Thomas, Wayne, van Bekkum, Margo, Sekyere, Eric, Jankowski, Kacper, Trahair, Toby, MacKenzie, Karen L., Haber, Michelle, Norris, Murray D., Biankin, Andrew V., Perini, Giovanni, Liu, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116909/
https://ncbi.nlm.nih.gov/pubmed/21698133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002135
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