SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK protein. Here we describe a novel positive feedba...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Marshall, Glenn M., Liu, Pei Y., Gherardi, Samuele, Scarlett, Christopher J., Bedalov, Antonio, Xu, Ning, Iraci, Nuncio, Valli, Emanuele, Ling, Dora, Thomas, Wayne, van Bekkum, Margo, Sekyere, Eric, Jankowski, Kacper, Trahair, Toby, MacKenzie, Karen L., Haber, Michelle, Norris, Murray D., Biankin, Andrew V., Perini, Giovanni, Liu, Tao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2011
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116909/
https://ncbi.nlm.nih.gov/pubmed/21698133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002135
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items