Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain

The human immunodeficiency virus (HIV) Tat protein plays an essential role in promoting efficient transcriptional elongation of viral transcripts. We report that the transcriptional co-activator PCAF and Tat interact and synergize to activate the HIV promoter. The binding of Tat and PCAF in vitro an...

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Publicado en:	EMBO J
Autores principales:	Dorr, Alexander, Kiermer, Veronique, Pedal, Angelika, Rackwitz, Hans-Richard, Henklein, Peter, Schubert, Ulrich, Zhou, Ming-Ming, Verdin, Eric, Ott, Melanie
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2002
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12032084/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.11.2715
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