Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain

The human immunodeficiency virus (HIV) Tat protein plays an essential role in promoting efficient transcriptional elongation of viral transcripts. We report that the transcriptional co-activator PCAF and Tat interact and synergize to activate the HIV promoter. The binding of Tat and PCAF in vitro an...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Dorr, Alexander, Kiermer, Veronique, Pedal, Angelika, Rackwitz, Hans-Richard, Henklein, Peter, Schubert, Ulrich, Zhou, Ming-Ming, Verdin, Eric, Ott, Melanie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12032084/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.11.2715
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