Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

Sirt3 is an NAD(+)-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal muscle resulting in increased mitochondrial protein acetylation. Deletion of Sirt3 led to impaired glucose oxidation...

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Hlavní autoři: Jing, Enxuan, O’Neill, Brian T., Rardin, Matthew J., Kleinridders, André, Ilkeyeva, Olga R., Ussar, Siegfried, Bain, James R., Lee, Kevin Y., Verdin, Eric M., Newgard, Christopher B., Gibson, Bradford W., Kahn, C. Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2013
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781465/
https://ncbi.nlm.nih.gov/pubmed/23835326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1650
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