Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, Rac activation is primarily mediated by DOCK2, an atypical guanine nucleotide exchange factor. Upon stimulat...

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Detalhes bibliográficos
Main Authors: Nishikimi, Akihiko, Fukuhara, Hideo, Su, Wenjuan, Hongu, Tsunaki, Takasuga, Shunsuke, Mihara, Hisashi, Cao, Qinhong, Sanematsu, Fumiyuki, Kanai, Motomu, Hasegawa, Hiroshi, Tanaka, Yoshihiko, Shibasaki, Masakatsu, Kanaho, Yasunori, Sasaki, Takehiko, Frohman, Michael A., Fukui, Yoshinori
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761877/
https://ncbi.nlm.nih.gov/pubmed/19325080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1170179
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