Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, Rac activation is primarily mediated by DOCK2, an atypical guanine nucleotide exchange factor. Upon stimulat...

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Main Authors: Nishikimi, Akihiko, Fukuhara, Hideo, Su, Wenjuan, Hongu, Tsunaki, Takasuga, Shunsuke, Mihara, Hisashi, Cao, Qinhong, Sanematsu, Fumiyuki, Kanai, Motomu, Hasegawa, Hiroshi, Tanaka, Yoshihiko, Shibasaki, Masakatsu, Kanaho, Yasunori, Sasaki, Takehiko, Frohman, Michael A., Fukui, Yoshinori
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761877/
https://ncbi.nlm.nih.gov/pubmed/19325080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1170179
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