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Molecular Mechanisms of N-Formyl-Methionyl-Leucyl-Phenylalanine-Induced Superoxide Generation and Degranulation in Mouse Neutrophils: Phospholipase D Is Dispensable

Phospholipase D (PLD), which produces the lipid messenger phosphatidic acid (PA), has been implicated in superoxide generation and degranulation in neutrophils. The basis for this conclusion is the observation that primary alcohols, which interfere with PLD-catalyzed PA production, inhibit these neu...

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Detalhes bibliográficos
Main Authors: Sato, Takanobu, Hongu, Tsunaki, Sakamoto, Megumi, Funakoshi, Yuji, Kanaho, Yasunori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536298/
https://ncbi.nlm.nih.gov/pubmed/23109426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00869-12
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