Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration

The migratory properties of lymphocytes depend on DOCK2, an atypical Rac activator predominantly expressed in hematopoietic cells. Although DOCK2 does not contain the Dbl homology domain typically found in guanine nucleotide exchange factors (GEFs), DOCK2 mediates the GTP-GDP exchange reaction for R...

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Detalhes bibliográficos
Main Authors: Terasawa, Masao, Uruno, Takehito, Mori, Sayako, Kukimoto-Niino, Mutsuko, Nishikimi, Akihiko, Sanematsu, Fumiyuki, Tanaka, Yoshihiko, Yokoyama, Shigeyuki, Fukui, Yoshinori
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458822/
https://ncbi.nlm.nih.gov/pubmed/23050005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046277
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