Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa

Forkhead transcription factors (FOXO) are downstream targets of the phosphoinositol-3-kinase (PI3K) protein kinase B (PKB) signaling cascade and play a pivotal role in cell differentiation, cell cycle and apoptosis. We found that cells from prednisone-resistant T-acute lymphoblastic leukemia (T-ALL)...

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Detalhes bibliográficos
Main Authors: Ausserlechner, Michael J., Salvador, Christina, Deutschmann, Andrea, Bodner, Martin, Viola, Giampietro, Bortolozzi, Roberta, Basso, Giuseppe, Hagenbuchner, Judith, Obexer, Petra
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759677/
https://ncbi.nlm.nih.gov/pubmed/23828551
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