The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma

Neuroblastoma is the most frequent extra-cranial solid tumor in children with still high mortality in stage M. Here we studied the tubulin-inhibitor MG-2477 as a possible therapeutic agent for neuroblastoma therapy and uncovered that MG-2477 induces death in neuroblastoma cells independent of PKB-ac...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hagenbuchner, Judith, Lungkofler, Lorena, Kiechl-Kohlendorfer, Ursula, Viola, Giampietro, Ferlin, Maria Grazia, Ausserlechner, Michael J., Obexer, Petra
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458265/
https://ncbi.nlm.nih.gov/pubmed/28415610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16434
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