Nuclear FOXO3 predicts adverse clinical outcome and promotes tumor angiogenesis in neuroblastoma

Neuroblastoma is the most frequent, extracranial solid tumor in children with still poor prognosis in stage IV disease. In this study, we analyzed FOXO3-phosphorylation and cellular localization in tumor biopsies and determined the function of this homeostasis regulator in vitro and in vivo. FOXO3-p...

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Udgivet i:Oncotarget
Main Authors: Hagenbuchner, Judith, Rupp, Martina, Salvador, Christina, Meister, Bernhard, Kiechl-Kohlendorfer, Ursula, Müller, Thomas, Geiger, Kathrin, Sergi, Consolato, Obexer, Petra, Ausserlechner, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363607/
https://ncbi.nlm.nih.gov/pubmed/27769056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12728
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