The Anti-apoptotic Protein BCL2L1/Bcl-xL Is Neutralized by Pro-apoptotic PMAIP1/Noxa in Neuroblastoma, Thereby Determining Bortezomib Sensitivity Independent of Prosurvival MCL1 Expression

Neuroblastoma is the most frequent extracranial solid tumor in children. Here, we report that the proteasome inhibitor bortezomib (PS-341, Velcade) activated the pro-apoptotic BH3-only proteins PMAIP1/Noxa and BBC3/Puma and induced accumulation of anti-apoptotic MCL1 as well as repression of anti-ap...

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Main Authors: Hagenbuchner, Judith, Ausserlechner, Michael J., Porto, Verena, David, Reinhard, Meister, Bernhard, Bodner, Martin, Villunger, Andreas, Geiger, Kathrin, Obexer, Petra
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
主題:
Signal Transduction
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844140/
https://ncbi.nlm.nih.gov/pubmed/20051518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038331
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