Repression of BIRC5/Survivin by FOXO3/FKHRL1 Sensitizes Human Neuroblastoma Cells to DNA Damage-induced Apoptosis

The phosphatidylinositol 3-kinase (PI3K)–protein kinase B (PKB) pathway regulates survival and chemotherapy resistance of neuronal cells, and its deregulation in neuroblastoma (NB) tumors predicts an adverse clinical outcome. Here, we show that inhibition of PI3K-PKB signaling in human NB cells indu...

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Hauptverfasser: Obexer, Petra, Hagenbuchner, Judith, Unterkircher, Thomas, Sachsenmaier, Nora, Seifarth, Christoph, Böck, Günther, Porto, Verena, Geiger, Kathrin, Ausserlechner, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663932/
https://ncbi.nlm.nih.gov/pubmed/19211844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-07-0699
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