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Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

PURPOSE: Several oral multikinase inhibitors are known to interact in vitro with the human ATP-binding cassette transporter ABCC4 (MRP4), but the in vivo relevance of this interaction remains poorly understood. We hypothesized that host ABCC4 activity may influence the pharmacokinetic profile of das...

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Detalhes bibliográficos
Main Authors: Furmanski, Brian D., Hu, Shuiying, Fujita, Ken-ichi, Li, Lie, Gibson, Alice A., Janke, Laura J., Williams, Richard T., Schuetz, John D., Sparreboom, Alex, Baker, Sharyn D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752901/
https://ncbi.nlm.nih.gov/pubmed/23794731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0980
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