Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha

Tumor necrosis factor alpha (TNF-α) has been demonstrated to inhibit steroidogenesis in Leydig cells at the transcriptional level of steroidogenic enzymes. However, the molecular mechanism of this observed gene repression is not well understood. We now demonstrate that nuclear factor κB (NF-κB) acti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hong, Cheol Yi, Park, Jin Hee, Ahn, Ryun Seop, Im, Suhn Young, Choi, Hueng-Sik, Soh, Jaemog, Mellon, Synthia H., Lee, Keesook
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2004
Pynciau:
Gene Expression
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC371106/
https://ncbi.nlm.nih.gov/pubmed/15024051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2593-2604.2004
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