Insulin Directly Regulates Steroidogenesis via Induction of the Orphan Nuclear Receptor DAX-1 in Testicular Leydig Cells

Testosterone level is low in insulin-resistant type 2 diabetes. Whether this is due to negative effects of high level of insulin on the testes caused by insulin resistance has not been studied in detail. In this study, we found that insulin directly binds to insulin receptors in Leydig cell membrane...

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Bibliographische Detailangaben
Hauptverfasser: Ahn, Seung Won, Gang, Gil-Tae, Kim, Yong Deuk, Ahn, Ryun-Sup, Harris, Robert A., Lee, Chul-Ho, Choi, Hueng-Sik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668749/
https://ncbi.nlm.nih.gov/pubmed/23589295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451773
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