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Insulin Directly Regulates Steroidogenesis via Induction of the Orphan Nuclear Receptor DAX-1 in Testicular Leydig Cells

Testosterone level is low in insulin-resistant type 2 diabetes. Whether this is due to negative effects of high level of insulin on the testes caused by insulin resistance has not been studied in detail. In this study, we found that insulin directly binds to insulin receptors in Leydig cell membrane...

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Bibliografski detalji
Glavni autori: Ahn, Seung Won, Gang, Gil-Tae, Kim, Yong Deuk, Ahn, Ryun-Sup, Harris, Robert A., Lee, Chul-Ho, Choi, Hueng-Sik
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668749/
https://ncbi.nlm.nih.gov/pubmed/23589295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451773
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