Insulin Directly Regulates Steroidogenesis via Induction of the Orphan Nuclear Receptor DAX-1 in Testicular Leydig Cells

Testosterone level is low in insulin-resistant type 2 diabetes. Whether this is due to negative effects of high level of insulin on the testes caused by insulin resistance has not been studied in detail. In this study, we found that insulin directly binds to insulin receptors in Leydig cell membrane...

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Hlavní autoři: Ahn, Seung Won, Gang, Gil-Tae, Kim, Yong Deuk, Ahn, Ryun-Sup, Harris, Robert A., Lee, Chul-Ho, Choi, Hueng-Sik
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668749/
https://ncbi.nlm.nih.gov/pubmed/23589295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451773
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