Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha

Tumor necrosis factor alpha (TNF-α) has been demonstrated to inhibit steroidogenesis in Leydig cells at the transcriptional level of steroidogenic enzymes. However, the molecular mechanism of this observed gene repression is not well understood. We now demonstrate that nuclear factor κB (NF-κB) acti...

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Bibliografske podrobnosti
Main Authors: Hong, Cheol Yi, Park, Jin Hee, Ahn, Ryun Seop, Im, Suhn Young, Choi, Hueng-Sik, Soh, Jaemog, Mellon, Synthia H., Lee, Keesook
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC371106/
https://ncbi.nlm.nih.gov/pubmed/15024051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2593-2604.2004
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