Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha

Tumor necrosis factor alpha (TNF-α) has been demonstrated to inhibit steroidogenesis in Leydig cells at the transcriptional level of steroidogenic enzymes. However, the molecular mechanism of this observed gene repression is not well understood. We now demonstrate that nuclear factor κB (NF-κB) acti...

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Bibliographic Details
Main Authors: Hong, Cheol Yi, Park, Jin Hee, Ahn, Ryun Seop, Im, Suhn Young, Choi, Hueng-Sik, Soh, Jaemog, Mellon, Synthia H., Lee, Keesook
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC371106/
https://ncbi.nlm.nih.gov/pubmed/15024051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2593-2604.2004
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