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Structure-based network analysis of an evolved G protein-coupled receptor homodimer interface

Crystallographic structures and experimental assays of human CXC chemokine receptor type 4 (CXCR4) provide strong evidence for the capacity to homodimerize, potentially as a means of allosteric regulation. Even so, how this homodimer forms and its biological significance has yet to be fully characte...

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Autori principali: Nichols, Sara E, Hernández, Carlos X, Wang, Yi, McCammon, James Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690714/
https://ncbi.nlm.nih.gov/pubmed/23553730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2258
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