Llwytho...

Free energy landscape of G-protein coupled receptors, explored by accelerated molecular dynamics

G-protein coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. They are known to adopt multiple conformational states (e.g., inactive, intermediate and active) during their modulation of var...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Miao, Yinglong, Nichols, Sara E., McCammon, J. Andrew
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960983/
https://ncbi.nlm.nih.gov/pubmed/24445284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cp53962h
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