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Free energy landscape of G-protein coupled receptors, explored by accelerated molecular dynamics

G-protein coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. They are known to adopt multiple conformational states (e.g., inactive, intermediate and active) during their modulation of var...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Miao, Yinglong, Nichols, Sara E., McCammon, J. Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960983/
https://ncbi.nlm.nih.gov/pubmed/24445284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cp53962h
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