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Graded activation and free energy landscapes of a muscarinic G-protein–coupled receptor
G-protein–coupled receptors (GPCRs) recognize ligands of widely different efficacies, from inverse to partial and full agonists, which transduce cellular signals at differentiated levels. However, the mechanism of such graded activation remains unclear. Using the Gaussian accelerated molecular dynam...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087018/ https://ncbi.nlm.nih.gov/pubmed/27791003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614538113 |
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