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Mechanism of the G-protein mimetic nanobody binding to a muscarinic G-protein-coupled receptor

Protein–protein binding is key in cellular signaling processes. Molecular dynamics (MD) simulations of protein–protein binding, however, are challenging due to limited timescales. In particular, binding of the medically important G-protein-coupled receptors (GPCRs) with intracellular signaling prote...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Miao, Yinglong, McCammon, J. Andrew
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866610/
https://ncbi.nlm.nih.gov/pubmed/29507218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800756115
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