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Mechanism of the G-protein mimetic nanobody binding to a muscarinic G-protein-coupled receptor
Protein–protein binding is key in cellular signaling processes. Molecular dynamics (MD) simulations of protein–protein binding, however, are challenging due to limited timescales. In particular, binding of the medically important G-protein-coupled receptors (GPCRs) with intracellular signaling prote...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5866610/ https://ncbi.nlm.nih.gov/pubmed/29507218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800756115 |
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