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Mechanism of the G-protein mimetic nanobody binding to a muscarinic G-protein-coupled receptor

Protein–protein binding is key in cellular signaling processes. Molecular dynamics (MD) simulations of protein–protein binding, however, are challenging due to limited timescales. In particular, binding of the medically important G-protein-coupled receptors (GPCRs) with intracellular signaling prote...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Miao, Yinglong, McCammon, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866610/
https://ncbi.nlm.nih.gov/pubmed/29507218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800756115
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