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Graded activation and free energy landscapes of a muscarinic G-protein–coupled receptor
G-protein–coupled receptors (GPCRs) recognize ligands of widely different efficacies, from inverse to partial and full agonists, which transduce cellular signals at differentiated levels. However, the mechanism of such graded activation remains unclear. Using the Gaussian accelerated molecular dynam...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087018/ https://ncbi.nlm.nih.gov/pubmed/27791003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614538113 |
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